Insight into the impingement of different sodium precursors on structural, biocompatible, and hemostatic properties...

Bioactive materials play a significant role in biomedical engineering for plethora of applications. To date, there is no evident report on the role of sodium precursors in structural changes towards their acceleration in biocompatibility. This study highlights the impact and role of two different sodium precursors (sodium nitrate and sodium hydroxide) on the structural changes and their potential formulations in biomineralization and biocompatibility. Structural characteristics enunciate the significant crystallization of NaCaPO₄, Na₂Ca₂Si₃O₉, and Na_1.8Ca_1.1Si₆O₁₄ phases with pertinent Q² stretching's while using sodium nitrate than sodium hydroxide. XPS spectra authenticate the elevated sodium content while using sodium nitrate as sodium precursor. One-dimensional structures with well faceted morphology and superior alkaline environment preferentially support the biomineralization and bactericidal properties in sodium nitrate-bioglass, was confirmed through structural, morphological, elemental, and antibacterial investigations. Whereas, higher blood and cell-line compatibility with elevated protein adsorption rate is perceived for the bioglass prepared using sodium hydroxide source, and subsequently, higher hemostatic properties are considerably observed with sodium nitrate-bioglass. Higher mechanical stability (ultrasonic measurements) and controlled degradation rate are the stratagems of sodium nitrate to boost the basic criteria of bioactive materials. Hence, it is proposed that sodium nitrate is a highly preferable source to develop bioactive and stable bioglass formulations.