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Treatment Volume, Dose Prescription and Delivery Techniques for Dose-intensification in Rectal Cancer: A National
Luciana Caravatta1, Marco Lupattelli2, Giovanna Mantello3
1Radiation Oncology Unit, "SS Annunziata" Hospital, "G. D'Annunzio" University, Chieti, Italy; lcaravatta@hotmail.com.
Background/Aim:
The aim of the study was to investigate boost volume definition, doses, and delivery techniques for rectal cancer dose intensification.
Patients And Methods:
An online survey was made on 25 items (characteristics, simulation, imaging, volumes, doses, planning and treatment).
Results:
Thirty-eight radiation oncologists joined the study. Twenty-one delivered long-course radiotherapy with dose intensification. Boost volume was delineated on diagnostic magnetic resonance imaging (MRI) in 18 centres (85.7%), and computed tomography (CT) and/or positron emission tomography-CT in 9 (42.8%); 16 centres (76.2%) performed co-registration with CT-simulation. Boost dose was delivered on gross tumor volume in 10 centres (47.6%) and on clinical target volume in 11 (52.4%). The most common total dose was 54-55 Gy (71.4%), with moderate hypofractionation (85.7%). Intensity-modulated radiotherapy (IMRT) was used in all centres, with simultaneous integrated boost in 17 (80.8%) and image-guidance in 18 (85.7%).
Conclusion:
A high quality of treatment using dose escalation can be inferred by widespread multidisciplinary discussion, MRI-based treatment volume delineation, and radiation delivery relying on IMRT with accurate image-guided radiation therapy protocols.
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