MORPHOLOGICAL CHARACTERISTICS OF SMALL INTESTINE MUCOSA IN DYSBIOSIS AND AFTER ITS CORRECTION BY PROBIOTICS AND
V Bobyr1, L Stechenko1, V Shyrobokov1
11Bohomolets National Medical University, Kyiv;Ukraine.
Georgian Medical News
|April 5, 2021
Summary
Antibiotics disrupt gut bacteria, causing small intestine damage. Probiotics and sorbents help restore microflora balance and reduce intestinal injury in antibiotic-induced dysbiosis.
Area of Science:
- Microbiology
- Gastroenterology
- Immunology
Background:
- Antibiotic use can lead to gut dysbiosis, altering the normal microbial balance.
- Dysbiosis is associated with pathological changes in the small intestine's mucosal layer.
- Immune responses are often dysregulated during antibiotic-induced dysbiosis.
Purpose of the Study:
- To investigate the effects of antibiotic-induced dysbiosis on the small intestine mucosa in mice.
- To evaluate the efficacy of probiotics and enterosorbents in correcting these dysbiotic changes.
- To assess the impact on the intestinal microbiome and host immune responses.
Main Methods:
- Induction of dysbiosis using antibiotics in BALB/c mice.
- Electron microscopy of small intestine, liver, and spleen samples.
- Fecal analysis for microbiome composition (bacterial isolation and identification).
Main Results:
- Antibiotics confirmed to induce dysbiosis, characterized by significant microflora shifts and epithelial damage.
- Probiotics demonstrated a notable reduction in cytodestructive disorders.
- Enterosorbents showed a lesser, but still observable, effect in mitigating damage and normalizing immune responses.
Conclusions:
- Antibiotic-induced dysbiosis causes significant damage to the small intestinal epithelium.
- Probiotics are effective in ameliorating antibiotic-induced gut damage and restoring immune balance.
- Enterosorbents offer partial benefits in managing dysbiosis-related intestinal pathology.
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