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Updated: Nov 10, 2025
08:07
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
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Factors Affecting Prognosis and Survival in Extremity Osteosarcoma
Anvesh Dharanikota1, Ravi Arjunan1, Ashwathappa Dasappa1
1Department of Surgical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India.
Indian Journal of Surgical Oncology
|April 5, 2021
Summary
Neoadjuvant chemotherapy and a good response to treatment significantly improve overall survival in extremity osteosarcoma patients. Absence of lung metastasis is crucial for long-term survival in these young patients.
Area of Science:
- Oncology
- Orthopedic Surgery
- Pediatric Oncology
Background:
- Osteosarcoma is a primary bone cancer predominantly affecting children and young adults.
- Extremity involvement is common in osteosarcoma, impacting patient prognosis.
- Understanding factors influencing survival is critical for optimizing treatment strategies.
Purpose of the Study:
- To identify patient-related, tumor-related, and treatment-related factors impacting overall survival.
- To evaluate the effectiveness of neoadjuvant chemotherapy in non-metastatic extremity osteosarcoma.
- To analyze the correlation between treatment response and patient outcomes.
Main Methods:
- Retrospective analysis of 100 non-metastatic extremity osteosarcoma cases (2014-2019).
- Data collected included demographics, histology, tumor site, chemotherapy details, surgical approach, recurrence, metastasis, and survival.
- Kaplan-Meier survival analysis with log-rank testing was employed.
Main Results:
- Median age was 18 years; distal femur was the most frequent site.
- Five-year overall survival was 65.5%; 5-year local recurrence-free survival was 57.6%.
- Neoadjuvant chemotherapy (80% OS) significantly improved survival compared to upfront surgery (39.5%). Tumor necrosis >90% and absence of lung metastasis also correlated with better survival.
Conclusions:
- Neoadjuvant chemotherapy is a significant predictor of improved overall survival.
- A strong response to chemotherapy, indicated by tumor necrosis, positively impacts survival.
- Preventing lung metastasis is vital for long-term survival in extremity osteosarcoma.
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