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Lignin: Drug/Gene Delivery and Tissue Engineering Applications.

Raj Kumar1, Arun Butreddy2, Nagavendra Kommineni3

  • 1Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

International Journal of Nanomedicine
|April 5, 2021
PubMed
Summary

Lignin, a renewable biopolymer, shows promise for biomedical uses like drug delivery and tissue engineering due to its unique properties. Further research is needed to overcome challenges and fully utilize this versatile natural material.

Keywords:
biomedical engineeringbiopolymerdrug deliveryligninnano-biosystemnanomedicinetissue engineering

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Lignin is an abundant, renewable natural biopolymer with significant potential.
  • Advances in lignin processing enable exploration of lignin-based bionanomaterials.
  • Lignin possesses antioxidant, antimicrobial, and biocompatible properties, making it attractive for biomedical uses.

Purpose of the Study:

  • To review recent advancements in lignin's application in biomedical fields, focusing on drug delivery and tissue engineering.
  • To highlight the unique properties of lignin that facilitate its use in biomedical applications.
  • To discuss current challenges and future prospects for lignin in nanomedicine.

Main Methods:

  • Literature review of recent scientific publications on lignin in biomedical applications.
  • Analysis of lignin's physicochemical and mechanical properties relevant to nanomedicine.
  • Synthesis and characterization of lignin-based nanoparticles and scaffolds.

Main Results:

  • Lignin's functionalization ease, diverse sites, and tunable properties are beneficial for biomedical applications.
  • Lignin exhibits favorable cell interactions and mimics the extracellular environment.
  • Significant progress has been observed in lignin-based drug delivery systems and tissue engineering scaffolds.

Conclusions:

  • Lignin is a highly promising biomaterial for drug delivery and tissue engineering due to its inherent properties and ease of modification.
  • Despite progress, challenges remain in identifying ideal nanomaterials for biomedical applications.
  • Future research should focus on overcoming these challenges to fully exploit lignin's potential in advanced biomedical applications.