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Osteocalcin and Abdominal Aortic Calcification in Hemodialysis Patients: An Observational Cross-Sectional Study

Fengyu Jia1, Suxia Wang1, Ying Jing1

  • 1Department of Nephrology, The 960th Hospital of the PLA Joint Logistics Support Force, Jinan, China.

Frontiers in Endocrinology
|April 5, 2021
PubMed

Insights

Serum osteocalcin (OC) levels are elevated in maintenance hemodialysis patients and correlate with vascular calcification. Higher OC is a risk factor for abdominal aortic calcification (AAC) in these patients.

Area of Science:

  • Nephrology
  • Endocrinology
  • Cardiovascular Medicine

Background:

  • Maintenance hemodialysis (MHD) patients often experience complications related to mineral and bone disorders.
  • Vascular calcification is a significant comorbidity in MHD patients, contributing to cardiovascular risk.

Purpose of the Study:

  • To investigate serum osteocalcin (OC) levels in MHD patients.
  • To determine the correlation between OC and abdominal aortic calcification (AAC) in this population.

Main Methods:

  • 108 adult MHD patients were enrolled between July 2017 and February 2020.
  • Serum OC, phosphorus, intact parathyroid hormone (iPTH), and fibroblast growth factor 23 (FGF23) were measured.
  • Abdominal aortic calcification score (AACs) was assessed, and data were analyzed using Pearson correlation and logistic regression.

Main Results:

  • MHD patients exhibited significantly elevated serum OC levels.
  • OC positively correlated with serum phosphorus, iPTH, and FGF23, and negatively with age.
  • Elevated OC levels were associated with higher AACs, and OC was identified as a risk factor for high AACs.

Conclusions:

  • Osteocalcin is significantly elevated in MHD patients and correlates with key markers of mineral metabolism.
  • Osteocalcin is implicated as a risk factor for vascular calcification, specifically abdominal aortic calcification, in MHD patients.
  • Further research is needed to differentiate the roles of carboxy-terminal OC (c-OC) and undercarboxylated OC (unOC) in vascular calcification.
Abstract

Keywords:
abdominal aortic calcificationchronic kidney disease-mineral and bone disordermaintenance hemodialysisosteocalcinvascular calcification

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