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Updated: Nov 10, 2025

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Curcumin micelles entrapped in eudragit S-100 matrix: a synergistic strategy for enhanced oral delivery
Helmy Yusuf1, Rizka Arifa Rahmawati1, M Agus Syamsur Rijal1
1Department of Pharmaceutics, Faculty of Pharmacy, Universitas Airlangga, Jl Mulyorejo Surabaya 60115, Indonesia.
Background:
Therapeutic activities of curcumin (CUR) via oral administration are hampered by the lack of bioavailability due to its poor water solubility and rapid degradation in GI tract.
Materials & Methods:
This preliminary study developed CUR micelle-eudragit S100 (EUD) dry powder (CM-EDP) spray-dried formulations. Poloxamer 407 was used as a micelle-forming agent and EUD as an entrapping matrix for protection over hydrolysis and enzymes in the GI tract.
Results:
The morphology of CM-EDP showed agglomeration with cratering on the surface of particles. Differential thermal analysis and x-ray diffractometry data exhibited evidence that CUR was converted into amorphous solid. An increased concentration of micelle-forming and dispersion matrix polymers resulted in a high fraction of drug being converted into the amorphous state. A significant increase in dissolution by 7-10 times was achieved compared with that of raw CUR.
Conclusion:
The present study disclosed the CM-EDP potency for future development of CUR oral formulation.
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