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Approaching Reactive Arthritis Associated With Poor Prognostic Factors: A Case Report and Literature Review.
Swetha Ann Alexander1, Eunjung Kim2, Ranadeep Mandhadi2
1Internal Medicine, University of Connecticut, Farmington, USA.
Cureus
|April 5, 2021
Summary
Reactive arthritis treatment primarily uses NSAIDs, followed by glucocorticoids or DMARDs. Novel therapies like adalimumab are increasingly used for patients with poor prognostic factors.
Area of Science:
- Rheumatology
- Immunology
- Pharmacology
Background:
- Reactive arthritis is an inflammatory condition often triggered by infection.
- Understanding its manifestations and diagnostic challenges is crucial for effective management.
Observation:
- A literature review identified current treatment practices for reactive arthritis.
- Focus was placed on therapies for patients with poor prognostic factors.
Findings:
- Non-steroidal anti-inflammatory drugs (NSAIDs) are the first-line treatment.
- Glucocorticoids and disease-modifying anti-rheumatic drugs (DMARDs) are subsequent options.
- Tumor necrosis factor inhibitors (TNFI), such as adalimumab, are increasingly used for severe cases.
Implications:
- Treatment choice for reactive arthritis depends on prognostic factors.
- Emerging therapies offer new hope for non-responders and severe disease presentations.
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