Related Experiment Video For b12 deficiency
Updated: Nov 10, 2025
Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
Published on: May 10, 2024
Rapid Development of Pernicious Anemia Unmasking Underlying Gastric Adenocarcinoma
Vihitha Thota1, Mahati Paravathaneni1, Verushka Bedi1
1Internal Medicine, Mercy Catholic Medical Center, Darby, USA.
Abstract:
Gastric cancer is one of the most common malignancies, often detected at later stages as patients remain asymptomatic until later stages. Pernicious anemia (PA), a well-known cause of vitamin B12 deficiency, is a classic risk factor for gastric cancer. Patients with PA usually present with megaloblastic anemia and peripheral neuropathy; however, they can also present with nonspecific symptoms. We describe below the case of a 56-year-old male who presented with symptoms of nausea, vomiting, and fatigue. Initial lab work revealed severe B12 deficiency, pancytopenia, and intramedullary hemolysis warranting endoscopy that revealed a gastric fundus mass significant for adenocarcinoma on biopsy.
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