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Updated: Nov 10, 2025

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

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Published on: April 28, 2019

Dengue Virus Non-Structural Protein 5 as a Versatile, Multi-Functional Effector in Host-Pathogen Interactions.

Priya Bhatnagar^1,2, Gopinathan Pillai Sreekanth², Kaja Murali-Krishna^2,3

¹Department of Biotechnology, TERI School of Advanced Studies, New Delhi, India.

Frontiers in Cellular and Infection Microbiology

|April 5, 2021

Summary

Dengue virus non-structural protein 5 (NS5) interacts with human proteins to disrupt antiviral defenses. This review details known and potential NS5 interactions, aiding understanding of dengue virus manipulation of host immunity.

Keywords:

Flavivirus NS5 antiviral immunity apoptosis moonlighting proteins protein–protein interactions (PPIs)signaling pathways spliceosome

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Published on: December 29, 2015

Area of Science:

Virology
Immunology
Molecular Biology

Background:

Dengue virus is a significant mosquito-borne viral disease.
The dengue virus NS5 protein is crucial for viral RNA replication and genome protection.
NS5 interferes with the human JAK-STAT pathway and interferon signaling.

Purpose of the Study:

To consolidate known and potential human protein interactors of dengue virus NS5.
To highlight significant NS5 interactors and their biological pathways.
To discuss the implications of NS5-host interactions for dengue pathogenesis and immune response.

Main Methods:

Literature review of experimental and computational studies.
Annotation and consolidation of NS5-interacting proteins.
Analysis of biological pathways and host immune response modulation.

Main Results:

Compilation of experimentally validated NS5 interactors.
Identification of potential NS5 interactors through computational approaches.
Characterization of key pathways, including JAK-STAT, affected by NS5.

Conclusions:

Dengue virus NS5 actively manipulates host cellular machinery and immune pathways.
Understanding NS5-host interactions is critical for developing antiviral strategies.
This review provides a foundation for further research into dengue virus pathogenesis.