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Inflammatory Pseudotumor: A 20-Year Single Institutional Experience.
Mustapha Akanji Ajani1,2, Ebenezer O Fatunla1, Francis A Onakpoma1
1Department of Pathology, University College Hospital, Ibadan, Oyo State, Nigeria.
Advanced Biomedical Research
|April 5, 2021
Summary
Inflammatory pseudotumor (IPT) predominantly affects adult females, with head and neck and gastrointestinal tract being the most common sites. Diagnostic challenges highlight the need to consider differential diagnoses for accurate IPT identification.
Area of Science:
- Pathology
- Oncology
- Histology
Background:
- Inflammatory pseudotumor (IPT) is a rare, benign neoplastic proliferation.
- Understanding IPT's demographics and presentation is crucial for diagnosis.
Purpose of the Study:
- To analyze the demographic distribution of IPT.
- To describe the clinical presentation and histomorphological features of IPT.
- To highlight diagnostic challenges associated with IPT.
Main Methods:
- Retrospective cross-sectional review of histologically confirmed IPT cases (1999-2018).
- Analysis of demographic data, clinical history, and histologic reports.
- Immunohistochemistry utilized for diagnostic dilemmas.
Main Results:
- 25 IPT cases identified, with ages ranging from 7 to 74 years (mean 38.96).
- Bimodal occurrence in the third and fifth decades, with a female preponderance (1:2.6 M:F ratio).
- Head and neck (44%) and gastrointestinal tract (40%) were most common sites; orbit comprised 73% of head/neck cases. Pain and swelling were common symptoms.
Conclusions:
- IPT exhibits a female predominance and commonly occurs in the head/neck and GI tract.
- Accurate diagnosis requires careful consideration of differential diagnoses.
- Histomorphological analysis and immunohistochemistry aid in challenging cases.
