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Updated: Nov 10, 2025
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Bullous Pemphigoid Associated with Multiple System Atrophy: Case Series
Andrew Snedden1,2, Jennifer Sharif3, John Newsham3
1Department of Neurology Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust Salford United Kingdom.
Background:
Bullous pemphigoid (BP) is an autoimmune blistering dermatosis associated with a number of neurological conditions, including idiopathic Parkinson's disease (IPD). Only 1 case of BP in a patient with multiple system atrophy (MSA) has been reported.
Cases:
We report 3 cases of men with probable MSA who developed bullous pemphigoid at a latency of 4-6 years from MSA symptom onset.
Conclusions:
Skin α-synuclein deposition in neurodegenerative conditions such as IPD and MSA may be a potential substrate for the exposure of BP-related antigens. Alternatively, central neurodegeneration may expose antigens as a substrate for cross-reactivity and BP pathogenesis. Our report suggests an association between BP and MSA, in addition to the previously documented association with IPD.
