Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

9.1K
Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
9.1K
Parallel Processing01:20

Parallel Processing

423
The brain processes sensory information rapidly due to parallel processing, which involves sending data across multiple neural pathways at the same time. This method allows the brain to manage various sensory qualities, such as shapes, colors, movements, and locations, all concurrently. For instance, when observing a forest landscape, the brain simultaneously processes the movement of leaves, the shapes of trees, the depth between them, and the various shades of green. This enables a quick and...
423
Open and closed-loop control systems01:17

Open and closed-loop control systems

1.3K
Control systems are foundational elements in automation and engineering. They are broadly categorized into open-loop and closed-loop systems. These classifications hinge on the presence or absence of feedback mechanisms, significantly influencing the system's performance, complexity, and application.
An open-loop control system operates without feedback from the output. It consists of two primary elements: the controller and the controlled process. The controller receives an input signal...
1.3K
Improving Translational Accuracy02:07

Improving Translational Accuracy

12.1K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
12.1K
Improving Translational Accuracy02:07

Improving Translational Accuracy

3.2K
3.2K
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

887
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
887

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Second Transapical Mitral Valve-in-Valve With a Stented Bovine Jugular Venous Valve in Shone's Complex.

JACC. Case reports·2026
Same author

Enhancing Explainable AI Stability with Realistic Synthetic Data for Cardiovascular Risk Prediction.

Studies in health technology and informatics·2026
Same author

Evaluating the effectiveness and roadside noise of alternative transverse rumble strip designs.

Scientific reports·2026
Same author

Knowledge graph embedding and alignment of incomplete electronic health records for critical care applications.

Journal of biomedical semantics·2026
Same author

Association Between Physical Activity and Serum 25-Hydroxyvitamin D Levels Among Adolescents in Northern Sudan: A School-Based Cross-Sectional Study.

Nutrients·2026
Same author

Rule-augmented constraint learning for semantic error detection in MIMIC-III knowledge graph.

International journal of medical informatics·2026
Same journal

DARUMA: a gateway to fast and easy prediction of intrinsically disordered regions.

PeerJ. Computer science·2026
Same journal

Alzheimer's disease detection using a quantum deep neural network with Haralick feature extraction and simulated annealing optimization.

PeerJ. Computer science·2026
Same journal

Network anomaly detection using Deep Autoencoder and parallel Artificial Bee Colony algorithm-trained neural network.

PeerJ. Computer science·2026
Same journal

An anomaly detection model for multivariate time series with anomaly perception.

PeerJ. Computer science·2026
Same journal

Retraction: A wormhole attack detection method for tactical wireless sensor networks.

PeerJ. Computer science·2026
Same journal

Evaluation of mental disorder with prioritization of its type by utilizing the bipolar complex fuzzy decision-making approach based on Schweizer-Sklar prioritized aggregation operators.

PeerJ. Computer science·2026
See all related articles

Related Experiment Video

Updated: Nov 10, 2025

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames
07:38

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames

Published on: April 11, 2019

13.1K

Towards FAIR protocols and workflows: the OpenPREDICT use case.

Remzi Celebi1, Joao Rebelo Moreira2, Ahmed A Hassan3

  • 1Institute of Data Science, Maastricht University, Maastricht, Netherlands.

Peerj. Computer Science
|April 5, 2021
PubMed
Summary
This summary is machine-generated.

Researchers can now make scientific workflows and data FAIR (Findable, Accessible, Interoperable, Reusable) using a novel approach. This method enhances reproducibility and data sharing in scientific research.

Keywords:
Drug repurposingFAIR data principlesFAIR workflowsOntology-driven healthcareReproducibilityResearch ObjectScientific workflows and protocolsSemantic web

More Related Videos

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.7K
A Real-Time Interactive System for Studying Confrontational Pursuit Behavior in Rodents
06:25

A Real-Time Interactive System for Studying Confrontational Pursuit Behavior in Rodents

Published on: May 16, 2025

880

Related Experiment Videos

Last Updated: Nov 10, 2025

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames
07:38

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames

Published on: April 11, 2019

13.1K
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.7K
A Real-Time Interactive System for Studying Confrontational Pursuit Behavior in Rodents
06:25

A Real-Time Interactive System for Studying Confrontational Pursuit Behavior in Rodents

Published on: May 16, 2025

880

Area of Science:

  • Computational Biology
  • Bioinformatics
  • Scientific Workflow Management

Background:

  • Scientific advancement relies on sharing, reusing, and reproducing research workflows and protocols.
  • The FAIR principles guide the management of research data to maximize its value and reusability.
  • Applying FAIR principles to scientific workflows and protocols presents unique challenges.

Purpose of the Study:

  • To present a two-fold approach for applying FAIR principles to scientific workflows and their associated data.
  • To evaluate this approach using the PREDICT drug repurposing workflow.
  • To demonstrate enhanced findability, reusability, and reproducibility of scientific workflows.

Main Methods:

  • Simultaneously applying FAIR principles to scientific workflows and their data.
  • FAIRification of datasets involved in the PREDICT workflow.
  • Utilizing semantic technologies and ontologies (Workflow4ever, PROV, EDAM, BPMN) to model protocols, workflow instructions, and execution traces.
  • Evaluating the semantic model through competency questions.

Main Results:

  • The OpenPREDICT workflow and its associated data were successfully FAIRified.
  • A novel semantic model was developed and evaluated for representing workflow components.
  • The approach demonstrated a high degree of adherence to FAIR principles for the OpenPREDICT workflow.
  • New types of competency questions regarding workflow details could be formulated and answered.

Conclusions:

  • The proposed approach effectively enhances the FAIRness of scientific workflows and data.
  • Semantic technologies provide a robust framework for managing and querying workflow information.
  • This work facilitates greater reproducibility and reusability in scientific research.