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Formation of Dispersible Taohong Siwu Tablets
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Optimizing the Formulation for Ginkgolide B Solid Dispersion.

Xiao Wu1, Qing Huo2, Qizhe Quan3

  • 1Department of Food Science, Beijing Union University, Beijing, 100023, China.

Open Life Sciences
|April 5, 2021
PubMed
Summary
This summary is machine-generated.

This study optimized Ginkgolide B (GB) solid dispersion using a solvent method. The new formulation significantly enhances GB

Keywords:
CrystalGinkgolide BRate of dissolutionSolid dispersion

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Ginkgolide B (GB) exhibits poor aqueous solubility, limiting its therapeutic applications.
  • Solid dispersion is a promising strategy to enhance the bioavailability of poorly soluble drugs.

Purpose of the Study:

  • To optimize the formulation of Ginkgolide B (GB) solid dispersion.
  • To improve the dissolution rate of GB in aqueous media.

Main Methods:

  • Solvent method utilizing ethanol:dichloromethane (1:1) solvent system.
  • Optimized formulation: GB:PVPK30 ratio of 1:10 with PVPK30 as the carrier.
  • Ultrasonic treatment at 60°C for 10 minutes.
  • Characterization using SEM, DSC, XRD, and particle size analysis.

Main Results:

  • Significant morphological changes observed in GB solid dispersion.
  • Complete transformation of crystalline GB to a non-crystalline, uniformly dispersed form within PVPK30.
  • Evidence of hydrogen bonding between GB and PVPK30, likely contributing to stabilization.
  • Enhanced dissolution of GB from 30% to 80% in aqueous solution.

Conclusions:

  • The optimized GB solid dispersion formulation effectively improves GB's aqueous solubility and dissolution rate.
  • The non-crystalline dispersion, stabilized by hydrogen bonding, is crucial for enhanced bioavailability.
  • This approach holds potential for developing solid dosage forms of GB.