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Related Experiment Videos

Improved diagnostic procedures in allergic RAST negative rhinitis.

G Valerio1, P Cassano, R Attimonelli

  • 1Divisione di Fisiopatologia Respiratoria, Policlinico di Bari, Italy.

Allergologia Et Immunopathologia
|January 1, 1988
PubMed
Summary

Chronic hyperreactive rhinitis patients may show positive allergy tests, but high nasal IgE levels don't always correlate. Diagnostic test criteria are critical for accurate rhinitis assessment.

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Area of Science:

  • Allergy and Immunology
  • Otorhinolaryngology (ENT)
  • Respiratory Medicine

Background:

  • Chronic hyperreactive rhinitis presents diagnostic challenges.
  • Distinguishing allergic from non-allergic rhinitis is crucial for effective treatment.
  • Existing diagnostic methods may yield variable results.

Purpose of the Study:

  • To evaluate diagnostic test performance in patients with chronic hyperreactive rhinitis.
  • To investigate the correlation between nasal IgE levels and positive allergy tests.
  • To differentiate early, delayed, and late-phase allergic reactions.

Main Methods:

  • Intradermal skin testing
  • Nasal provocation testing
  • Measurement of specific IgE in nasal fluids and serum

Related Experiment Videos

  • RAST (Radioallergosorbent test) on nasal fluids
  • Assessment of delayed and late positive provocation tests

    • Main Results:

    • 15/28 patients with cutinegative, RAST-negative rhinitis had positive intradermal tests, nasal provocation tests, and nasal fluid RAST.
    • 13/28 patients showed high nasal IgE, but rarely had positive intradermal tests, and never positive nasal provocation or nasal RAST.
    • Delayed and late positive provocation tests exhibited distinct characteristics compared to early reactions.

    Conclusions:

    • Diagnostic criteria and monitoring during provocation tests are critical for rhinitis assessment.
    • The presence of sinusitis and nasal polyposis can alter clinical presentations.
    • Tissue-released mediators contribute to the development of bronchial hyperreactivity.