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Bullous Prurigo Pigmentosa.
1Department of Dermatology, the People's Hospital of Fenghua Ningbo, Zhejiang Province 315500 PR China.
Open Life Sciences
|April 5, 2021
Summary
Bullous Prurigo pigmentosa (PP) is a rare inflammatory skin condition. Minocycline hydrochloride effectively treated a patient
Area of Science:
- Dermatology
- Immunopathology
Background:
- Prurigo pigmentosa (PP) is an inflammatory dermatosis of unknown cause.
- Clinical presentation varies, with rare cases showing vesicles and bullae.
Purpose of the Study:
- To report a case of bullous prurigo pigmentosa.
- To describe the clinical, pathological, and therapeutic aspects of this rare condition.
Main Methods:
- Case presentation of a 29-year-old woman with a 6-year history of relapsing pruritic lesions.
- Physical examination, skin biopsy with histological examination, and direct immunofluorescence.
- Treatment with minocycline hydrochloride.
Main Results:
- The patient presented with erythematous plaques, vesicles, bullae, and mottled pigmentation.
- Histopathology revealed a lichenoid reaction with intraepidermal bulla.
- Complete resolution of rash occurred within 3 weeks of minocycline therapy, with subsequent pigmentation.
Conclusions:
- Bullous prurigo pigmentosa is a distinct clinical variant of PP.
- Minocycline hydrochloride is an effective treatment for bullous prurigo pigmentosa.
- The condition showed no recurrence during a 4-year follow-up.
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