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Engineering precision therapies: lessons and motivations from the clinic
Mingqi Xie1,2,3, Mirta Viviani1,2,3, Martin Fussenegger4,5
1Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou 310024, Zheijang, China.
Synthetic Biology (Oxford, England)
|April 5, 2021
Summary
Synthetic biology has revolutionized gene and cell therapies by enabling precise control over genetic activities. This review covers approved treatments and promising preclinical research for complex human diseases.
Area of Science:
- Biomedical Engineering
- Molecular Biology
- Genetics
Background:
- Gene and cell-based therapies represent a major advance in medicine.
- Synthetic biology provides essential tools for precise genetic regulation in these therapies.
Purpose of the Study:
- To review approved gene and cell-based therapies enabled by synthetic biology.
- To discuss preclinical advancements for future therapeutic applications.
Main Methods:
- Review of approved therapeutic technologies.
- Analysis of preclinical research findings.
Main Results:
- Several synthetic biology-driven therapies are approved for human use.
- Promising preclinical studies show potential for enhanced efficacy and new treatments.
Conclusions:
- Synthetic biology is a key driver of innovation in gene and cell therapies.
- Future research holds promise for treating currently intractable diseases with precision medicine.
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