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Chinese herb microneedle patch for wound healing.

Junjie Chi1, Lingyu Sun2,3, Lijun Cai2,3

  • 1Translational Medicine Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, China.

Bioactive Materials
|April 5, 2021
PubMed
Summary

A novel Chinese herb microneedle (CHMN) patch combines Premna microphylla and Centella asiatica extracts for advanced wound healing. This innovative approach demonstrates significant antibacterial and anti-inflammatory properties, promoting effective tissue regeneration.

Keywords:
Asiatic acidChinese herbMicroneedlePatchWound healing

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Area of Science:

  • Biomaterials Science
  • Traditional Chinese Medicine
  • Dermatology

Background:

  • Traditional Chinese medicine (TCM) and herbal remedies offer therapeutic benefits for various conditions.
  • Developing novel delivery systems for TCM enhances convenience and application range.
  • Microneedle technology presents a promising platform for transdermal drug delivery.

Purpose of the Study:

  • To develop a novel Chinese herb microneedle (CHMN) patch for wound healing.
  • To integrate Premna microphylla and Centella asiatica extracts into a microneedle system.
  • To evaluate the efficacy of the CHMN patch in promoting wound closure and tissue regeneration.

Main Methods:

  • Extraction of herbal sap from Premna microphylla and Centella asiatica leaves using a traditional kneading method.
  • Solidification of herbal extracts with plant ash derived from tofu processing.
  • Fabrication of microneedles using a well-designed mold.
  • In vitro and in vivo evaluation of antibacterial, anti-inflammatory, and wound healing properties.

Main Results:

  • The CHMN patch exhibited significant antibacterial activity and effectively inhibited inflammation.
  • The microneedle formulation promoted collagen deposition and angiogenesis.
  • Demonstrated enhanced tissue reconstruction and accelerated wound closure.
  • The CHMN patch showed potent antioxidant properties.

Conclusions:

  • The developed CHMN patch effectively integrates TCM principles with microneedle technology for wound healing.
  • Premna microphylla and Centella asiatica extracts provide multifaceted therapeutic benefits, including antibacterial, anti-inflammatory, and regenerative effects.
  • This innovative approach highlights the potential of combining traditional medicine with modern technologies for improved healthcare solutions.