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Related Experiment Videos

Selenium status and the polyp-cancer sequence: a colonoscopically controlled study.

B M Dworkin1, W S Rosenthal, A Mittelman

  • 1Sarah C. Upham Division of Gastroenterology, New York Medical College, Valhalla.

The American Journal of Gastroenterology
|July 1, 1988
PubMed
Summary
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Low selenium levels are not linked to the initial development of colon polyps. However, selenium levels decrease as colon cancer progresses from polyp to metastatic stages.

Area of Science:

  • Oncology
  • Nutritional Science
  • Gastroenterology

Background:

  • Diminished blood selenium is linked to increased gastrointestinal cancer risk.
  • Dietary selenium reduces experimental colon cancer in rats.
  • No prior data existed on selenium's role in colon polyp to cancer progression.

Purpose of the Study:

  • To investigate the association between selenium levels and the progression of colon cancer from benign polyps to metastatic disease.
  • To assess selenium's influence on the polyp-to-cancer sequence in humans.

Main Methods:

  • Measured plasma and erythrocyte selenium levels in patients with adenomatous polyps (Group I), local colon cancer (Group II), metastatic colon cancer (Group III), and controls (Group IV).
  • Patients were evaluated via colonoscopy and histology.

Related Experiment Videos

  • Statistical analysis (ANOVA) was used to compare selenium levels across groups.

    • Main Results:

    • No significant difference in selenium levels was found between controls (Group IV) and patients with polyps (Group I) or local cancer (Group II).
    • Selenium levels progressively decreased from polyps (Group I) to local cancer (Group II) to metastatic cancer (Group III) (p=0.028).
    • Parallel changes in plasma and erythrocyte selenium suggest long-term selenium abnormalities.

    Conclusions:

    • Selenium stores do not appear to be a significant factor in the initial formation of benign colonic polyps.
    • While selenium levels decrease with cancer progression, the data do not support a significant role for selenium in the overall colon polyp-to-cancer sequence.
    • A subset of patients with polyps and very low selenium may have a higher risk of malignant transformation.