Related Experiment Video
Updated: Nov 10, 2025
06:15
Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
12.3K
Ternary solid dispersions: classification and formulation considerations.
Shambhavi Borde1, Sagar Kumar Paul1, Harsh Chauhan1
1School of Pharmacy and Health Professions, Creighton University, Omaha, NE, USA.
Drug Development and Industrial Pharmacy
|April 5, 2021
Summary
Ternary solid dispersions (TSD) enhance the solubility and bioavailability of poorly water-soluble drugs. This advanced formulation approach improves drug performance for oral dosage forms.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Formulation Development
Background:
- Increasing number of Biopharmaceutical Classification System (BCS) Class II and IV compounds with poor aqueous solubility.
- These poorly soluble drugs possess high therapeutic potential but face formulation challenges for oral delivery.
- Traditional formulation approaches like amorphous solid dispersions (ASD) have shown success.
Purpose of the Study:
- To review the advancements in ternary solid dispersions (TSD) for improving drug solubility and bioavailability.
- To discuss the classification, mechanisms, preparation, and characterization of TSD.
- To highlight TSD as a promising formulation strategy for poorly water-soluble drugs.
Main Methods:
- Literature review on ternary solid dispersions (TSD).
- Discussion of formulation strategies including amorphous solid dispersions (ASD) and TSD.
- Analysis of preparation techniques and characterization methods for TSD.
Main Results:
- TSD, an advancement of ASD, incorporates an additional component to enhance solubility, stability, and processability.
- Various formulation approaches are discussed for improving the performance of poorly water-soluble compounds.
- TSD offers improved solubility and bioavailability compared to conventional methods.
Conclusions:
- Ternary solid dispersions represent a significant advancement in formulating poorly water-soluble drugs.
- TSD formulations can overcome the challenges associated with BCS Class II and IV compounds.
- Further research and application of TSD are crucial for developing effective oral dosage forms.
Related Concept Videos
01:27Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence
51
Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
51
03:22Colloids
19.3K
Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
19.3K
01:21Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
489
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
489
01:09Colloidal precipitates
2.3K
The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
2.3K
01:28Factors Influencing Drug Absorption: Pharmaceutical Parameters
251
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
251
01:17Colloids and Suspensions
2.6K
Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles visible to the naked eye or seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. The suspended particles in a suspension settle out after some time of mixing. The separation of particles from a suspension is...
2.6K