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Related Experiment Videos

The evaluation of the data collection process for a multicenter, population-based, case-control design.

P A Wingo1, H W Ory, P M Layde

  • 1Division of Reproductive Health, Centers for Disease Control, Atlanta, GA 30333.

American Journal of Epidemiology
|July 1, 1988
PubMed
Summary

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This study on oral contraceptive use and cancer provides a practical guide for large case-control studies. It highlights effective methods for case identification, control screening, and data validation in cancer research.

Area of Science:

  • Epidemiology
  • Oncology
  • Public Health

Background:

  • Large-scale case-control studies are crucial for understanding cancer risk factors.
  • Oral contraceptive use has been a subject of interest regarding its association with various cancers.

Purpose of the Study:

  • To detail the methods and rationale for the Cancer and Steroid Hormone Study.
  • To provide a practical guide for planning and conducting population-based case-control studies.
  • To evaluate oral contraceptive use in relation to breast, endometrial, and ovarian cancer.

Main Methods:

  • Utilized the Surveillance, Epidemiology, and End Results (SEER) program for case identification.
  • Employed random digit dialing for efficient screening of eligible controls.
  • Collaborated with community pathologists for histologic slide review and cancer subclassification.
Keywords:
AmericasBreast CancerCaliforniaCancerConnecticutContraceptionContraceptive Agents, Female--side effectsContraceptive Agents--side effectsContraceptive HistoryContraceptive Methods--side effectsContraceptive UsageData CollectionDeveloped CountriesDeveloping CountriesDiseasesEndometrial CancerEpidemiologic MethodsFamily PlanningGeorgiaHealthHealth SurveysInformationInformation ProcessingInterviewsIowaMeasurementMichiganNeoplasmsNew MexicoNorth AmericaNorthern AmericaOral Contraceptives--side effectsOvarian CancerProspective StudiesRecordsReliabilityResearch MethodologyRisk FactorsSampling StudiesSteroid Metabolic EffectsStudiesSurvey MethodologySurveysUnited StatesUtahWashington

Related Experiment Videos

  • Validated self-reported medical history through review of medical records.

    • Main Results:

    • The SEER program is a valuable resource for cancer epidemiology in the U.S.
    • Random digit dialing proved effective for control recruitment in population-based studies.
    • Histologic confirmation and subclassification exceeded 95% for interviewed cases.
    • Medical record review validated over 75% of reported medical events.

    Conclusions:

    • The documented methods offer a robust framework for future large case-control studies.
    • Effective strategies were identified for case ascertainment, control selection, and data integrity.
    • The study successfully gathered data on oral contraceptive use and its potential link to specific cancer types.