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Risk factors for mortality among admitted children with complications of measles in Pakistan: An observational study

Brekhna Aurangzeb1, Areesh Fatmee2, Rehmana Waris1

  • 1Children Hospital, Pakistan Institute of Medical Sciences, Islamabad, Pakistan.

JPMA. the Journal of the Pakistan Medical Association
|April 5, 2021
PubMed

Insights

Measles complications are deadly for unvaccinated children. Factors like encephalitis, stunting, and malnutrition increase mortality risk in pediatric measles cases.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Measles is a highly contagious viral illness that can lead to severe complications.
  • Vaccination is a critical preventive measure against measles and its sequelae.
  • Understanding risk factors for mortality is essential for improving outcomes in affected children.

Purpose of the Study:

  • To determine the vaccination status of children admitted with measles complications.
  • To identify risk factors associated with mortality in these children.

Main Methods:

  • A retrospective study was conducted using data from children admitted with measles complications between 2013 and 2017.
  • Data on vaccination history, complications, anthropometry, and outcomes were collected from hospital records.
  • Statistical analysis was performed using Stata 14.

Main Results:

  • Out of 228 subjects, 109 (47.8%) were unvaccinated against measles.
  • Mortality was significantly associated with unvaccinated status, stunting, and encephalitis.
  • A total of 39 (17%) children died within 15 days of admission.

Conclusions:

  • Encephalitis, lack of measles vaccination, and under-nutrition are significant risk factors for mortality.
  • These findings highlight the importance of vaccination and nutritional support in managing measles complications.
Abstract

Keywords:
Child, Measles, Risk factors, Mortality, Vaccination.

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