Related Experiment Video
Updated: Nov 10, 2025

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
Published on: August 31, 2022
When Too Many Hits Break the Heart: A Case of Radiation Induced Takotsubo Cardiomyopathy
1Department of Internal Medicine, Atlantic Health System, Morristown, NJ, USA.
Abstract:
Takotsubo cardiomyopathy (TCM), or stress induced cardiomyopathy is being increasingly recognized as a cause of acute heart failure. Often seen in women and older individuals with acute stressors, it can cause significant hemodynamic compromise. Here we report a case of a 78 year old woman who developed sudden chest pain following radiation therapy for B-Cell lymphoma. Echocardiogram revealed newly reduced ejection fraction and cardiac catheterization showed non obstructive coronary disease. Left ventriculogram revealed apical ballooning, characteristic of TCM. Often linked to physical and emotional stressors, TCM has been found to be more prevalent in patients with malignancies.
Related Concept Videos
Myocarditis I: Introduction
Myocarditis II: Clinical Features and Diagnostic Tests
Acute Coronary Syndrome III: Diagnostic Studies
Cardiomyopathy IV: Restrictive Cardiomyopathy
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Myocarditis IV: Nursing Management

