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Effects of flame retardants on ovarian function
Xiaotong Wang1, Barbara F Hales1, Bernard Robaire2
1Departments of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
Reproductive Toxicology (Elmsford, N.Y.)
|April 5, 2021
Summary
Flame retardants, including PBDEs, HBCDD, TBBPA, and OPEs, are widespread environmental contaminants. This review examines their impact on female reproductive health, specifically ovarian function and fertility.
Area of Science:
- Environmental Science
- Toxicology
- Reproductive Biology
Background:
- Flame retardants are common in consumer products and the environment.
- Polybrominated diphenyl ethers (PBDEs) are linked to adverse health effects, leading to their replacement.
- Alternative flame retardants like HBCDD, TBBPA, and OPEs are increasingly used.
Purpose of the Study:
- To review the effects of brominated and organophosphate ester flame retardants on ovarian function.
- To explore potential mechanisms underlying these effects on female fertility.
Main Methods:
- Literature review of epidemiological, in vivo, and in vitro studies.
- Synthesis of existing evidence on flame retardant exposure and ovarian health.
Main Results:
- Some flame retardants are associated with ovarian dysfunction.
- The impact of many current flame retardants on the ovary requires further investigation.
Conclusions:
- Brominated and organophosphate ester flame retardants may pose risks to female reproductive health.
- Further research is needed to fully understand the ovarian toxicity of these widely used chemicals.
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