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Updated: Nov 10, 2025
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
39.2K
Immunotherapy in psoriasis
Lilla Landeck1, Robert Sabat2, Kamran Ghoreschi3
1Department of Dermatology, Ernst von Bergmann General Hospital, Potsdam 14467, Germany.
Immunotherapy
|April 6, 2021
Summary
Biological treatments for psoriasis targeting cytokines have advanced significantly. This review overviews approved biologic drugs, their mechanisms, and selection criteria for effective psoriasis management.
Area of Science:
- Immunology
- Dermatology
- Pharmacology
Background:
- Psoriasis treatment has evolved with targeted therapies.
- Biological drugs now target key inflammatory cytokines in the human cytokine network.
- Eleven biologic agents (antibodies and a soluble receptor) are currently approved.
Purpose of the Study:
- To provide an overview of approved biologicals for psoriasis treatment.
- To discuss the advantages and limitations of each biologic class.
- To summarize criteria for selecting the optimal therapy for individual patients.
Main Methods:
- Review of approved biological therapies for psoriasis.
- Classification of biologics based on cytokine targets: TNF-α, IL-12/23, IL-17, and IL-23 inhibitors.
- Analysis of drug mechanisms, efficacy, and safety profiles.
Main Results:
- Four main classes of biologics are available: TNF-α, IL-12/23, IL-17, and IL-23 inhibitors.
- Each class offers distinct advantages and limitations in treating psoriasis.
- Therapy selection requires careful consideration of patient-specific factors.
Conclusions:
- The landscape of biologic psoriasis treatment is diverse, offering personalized options.
- Understanding the different biologic classes and their targets is crucial for effective management.
- A systematic approach to therapy selection optimizes patient outcomes in psoriasis care.
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