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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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What is Cancer?02:12

What is Cancer?

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Related Experiment Video

Updated: Nov 10, 2025

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
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Cancer and stem cells.

Wen Yin1, Jialing Wang1, Linling Jiang1

  • 1Regenerative Medicine Research Center, Sichuan University West China Hospital, Sichuan 610041, China.

Experimental Biology and Medicine (Maywood, N.J.)
|April 6, 2021
PubMed
Summary
This summary is machine-generated.

Cancer stem cells play a crucial role in tumor formation, spread, and relapse. Understanding their influence offers potential for new cancer therapies.

Keywords:
Cancercancer stem cellsmetastasisstem cellstumor microenvironmenttumorigenesis

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Area of Science:

  • Oncology and Cancer Research
  • Stem Cell Biology
  • Biomedical Science

Background:

  • Cancer is a leading global cause of death, with ongoing research into its origins, progression, and recurrence.
  • Despite extensive study, the fundamental mechanisms of cancer remain incompletely understood.
  • Stem cells are increasingly recognized for their potential roles in various biological processes, including disease.

Purpose of the Study:

  • To examine evidence linking stem cells to cancer development (tumorigenesis) and spread (metastasis).
  • To investigate the reciprocal relationship between cancer and stem cells within the tumor microenvironment.
  • To explore the implications of cancer stem cell biology for future cancer treatment strategies.

Main Methods:

  • Literature review and evidence synthesis.
  • Analysis of existing research on stem cell properties and cancer biology.
  • Exploration of the tumor microenvironment's influence on stem cells.

Main Results:

  • Evidence suggests a significant role for stem cells in cancer initiation, progression, and relapse.
  • Cancer influences stem cells, which are integral components of the tumor microenvironment.
  • The unique properties of cancer stem cells are critical to understanding tumor behavior.

Conclusions:

  • Cancer stem cells are implicated in tumorigenesis, metastasis, and recurrence.
  • The interaction between cancer and stem cells highlights their importance in the tumor microenvironment.
  • Targeting cancer stem cells presents a promising avenue for developing next-generation cancer therapies.