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Evaluation of cycle threshold values at deisolation.

Clayton T Mowrer1, Hannah Creager2, Kelly Cawcutt1

  • 1Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, Nebraska.

Infection Control and Hospital Epidemiology
|April 6, 2021
PubMed
Summary
This summary is machine-generated.

Discontinuing isolation for hospitalized patients with persistent SARS-CoV-2 positivity requires careful clinical evaluation. Expert consultation and cycle threshold values aid decisions on ending isolation protocols.

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Area of Science:

  • Infectious Diseases
  • Clinical Medicine
  • Virology

Background:

  • Hospitalized patients with severe acute respiratory coronavirus virus 2 (SARS-CoV-2) may have persistent positive molecular test results.
  • Decisions regarding the discontinuation of isolation for these patients are complex.

Purpose of the Study:

  • To explore the nuanced factors influencing the decision to discontinue isolation in hospitalized patients with persistently positive SARS-CoV-2 molecular testing.
  • To highlight the role of clinical improvement and expert consultation in this decision-making process.

Main Methods:

  • Review of clinical guidelines and expert opinion on SARS-CoV-2 isolation protocols.
  • Analysis of the utility of molecular testing parameters, such as cycle threshold (Ct) values, in conjunction with clinical assessment.

Main Results:

  • Discontinuation of isolation is not solely based on persistent positive molecular tests.
  • Clinical status improvement is a primary consideration, often requiring expert medical advice.
  • Cycle threshold values can provide supplementary information to guide isolation decisions.

Conclusions:

  • The decision to stop isolation for patients with persistent SARS-CoV-2 positivity is multifactorial.
  • Integrating clinical assessment, expert consultation, and molecular data like Ct values optimizes patient care and resource allocation.
  • Further research may refine criteria for isolation discontinuation in specific patient populations.