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Nonlinear structural and material properties and models: the pulmonary trunk.

J Melbin1, S Summerfield, A Noordergraaf

  • 1Department of Animal Biology, University of Pennsylvania, Philadelphia 19104.

Annals of Biomedical Engineering
|January 1, 1988
PubMed
Summary
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New models predict the static and dynamic responses of main pulmonary arteries. These models account for nonlinear, viscoelastic, and thixotropic tissue properties, crucial for accurate biomaterial evaluations.

Area of Science:

  • Biomaterial science
  • Cardiovascular mechanics
  • Biophysics

Background:

  • Understanding the mechanical properties of blood vessels is crucial for diagnosing and treating cardiovascular diseases.
  • Pulmonary artery mechanics are complex, influenced by static, dynamic, nonlinear, and frequency-dependent factors.

Purpose of the Study:

  • To develop general models for static and dynamic geometric and material passive responses of main pulmonary arteries.
  • To investigate the influence of nonlinear and colloidal tissue properties on functional responses.

Main Methods:

  • Developed general models for static and dynamic responses.
  • Applied models to data from calf and dog main pulmonary arteries.
  • Utilized a five-element material model to obtain parameters for predicting viscoelastic responses.

Related Experiment Videos

  • Investigated inactivated smooth muscle states using potassium cyanide.

    • Main Results:

    • The structural model concisely predicts simultaneous stretching and bending distortions.
    • The material model predicts nonlinear, frequency-dependent, viscoelastic responses across the entire strain range.
    • Analysis revealed that nonlinear (strain-dependent) and colloidal (thixotropic) properties significantly impact functional responses.

    Conclusions:

    • Evaluations of biomaterial responses, particularly in pulmonary arteries, must account for nonlinear and thixotropic properties.
    • These properties can substantially modify concepts of material components and vary between physiological and laboratory conditions.