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Diffuse large B-cell lymphoma: new targets and novel therapies

Bruce D Cheson1, Grzegorz Nowakowski2, Gilles Salles3

  • 1Lymphoma Research Foundation, New York, NY, USA. bdcheson@gmail.com.

Blood Cancer Journal
|April 6, 2021
PubMed

Insights

New therapies are needed for diffuse large B-cell lymphoma (DLBCL). Approved and emerging treatments, including targeted therapies and CAR-T cells, offer new hope for B-cell malignancy patients.

Area of Science:

  • Hematology
  • Oncology
  • Immunotherapy

Background:

  • Diffuse large B-cell lymphoma (DLBCL) and other B-cell malignancies require novel, non-cytotoxic treatments.
  • Current treatment options have limitations, highlighting an unmet clinical need.

Purpose of the Study:

  • To review recent advancements in therapies for B-cell malignancies.
  • To discuss the potential of emerging targeted therapies and immunotherapies.

Main Methods:

  • Literature review of recently approved and investigational agents for B-cell malignancies.
  • Analysis of current treatment landscape, including targeted therapies, antibody-drug conjugates, bispecific antibodies, and CAR-T cell therapies.

Main Results:

  • Several new agents are approved, including polatuzumab, selinexor, and tafasitamab.
  • Three chimeric antigen receptor T-cell (CAR-T) therapies are FDA-approved, with more in development.
  • Bispecific antibodies and antibody-drug conjugates represent promising future therapeutic avenues.

Conclusions:

  • Combinations of targeted therapies are expected to improve outcomes for patients with B-cell malignancies.
  • The evolving landscape of novel agents offers significant potential for enhanced patient care.

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