Management of osteoporosis in older men
1Department of Endocrinology, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Gent, Belgium. jean.kaufman@ugent.be.
Insights
Osteoporosis affects one in three men, leading to worse outcomes for fractures. Early diagnosis and treatment are crucial but underutilized in older men.
Area of Science:
- Gerontology
- Orthopedics
- Endocrinology
Background:
- Osteoporosis and fragility fractures pose significant health risks for older men, with poorer outcomes compared to women.
- Despite available diagnostic tools and treatments, a small percentage of high-risk older men receive osteoporosis therapy.
- The societal and individual burden of osteoporosis in men necessitates improved management strategies.
Purpose of the Study:
- To review the current evidence on osteoporosis and fragility fractures in older men.
- To highlight the burden, pathophysiology, diagnosis, and management of osteoporosis in this demographic.
- To inform clinical practice and research regarding male osteoporosis.
Main Methods:
- This narrative review synthesizes existing literature on osteoporosis in older men.
- It covers epidemiology, pathophysiology, clinical presentation, risk assessment, and treatment options.
- Evidence from clinical trials and observational studies is summarized.
Main Results:
- Fragility fractures are common in older men, with hip fractures having worse outcomes than in women.
- Underdiagnosis and undertreatment of osteoporosis are prevalent in high-risk older men.
- Effective diagnostic tools and therapeutic agents are available but underutilized.
Conclusions:
- Osteoporosis in older men is a significant, under-addressed health issue.
- Improved awareness, risk assessment, and timely treatment are essential for better patient outcomes.
- Further research is needed to strengthen the evidence base for managing male osteoporosis.
Abstract:
As many as one out of three fragility fractures occur in older men and the outcome of major osteoporotic fractures, in particular hip fractures, is worse in men than in women. Osteoporosis in older men is thus an important threat to the quality of life of individual patients and a considerable burden for society. However, only a small minority of older men with high or very high fracture risk are receiving therapy. This does not need to be so as tools for fracture risk assessment are available and several drugs have been approved for treatment. Nevertheless, the evidence base for the management of osteoporosis in older men remains limited. This narrative review summarises the evidence for older men on the burden of osteoporosis, the pathophysiology of fragility fractures, the clinical presentation, diagnosis and risk assessment, the patient evaluation, and the non-pharmacological and pharmacological management.
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