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Cerebrospinal Fluid

Cerebrospinal Fluid

Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain....

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Related Experiment Video

Updated: Nov 10, 2025

A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side

A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side

Published on: May 6, 2016

Cerebrospinal fluid proteome maps detect pathogen-specific host response patterns in meningitis.

Anahita Bakochi¹, Tirthankar Mohanty¹, Paul Theodor Pyl²

¹Department of Clinical Sciences, Division of Infection Medicine, Lund University, Lund, Sweden.

|April 6, 2021

Summary

Researchers identified specific protein patterns in cerebrospinal fluid (CSF) to distinguish between bacterial and viral meningitis. This proteomic analysis aids in diagnosing meningitis types and predicting outcomes.

Keywords:

cerebrospinal fluid human infectious disease meningitis microbiology proteomics

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A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

Published on: October 20, 2016

Area of Science:

Neuroscience
Infectious Diseases
Proteomics

Background:

Meningitis, an inflammation of the leptomeningeal membranes, poses significant health risks.
Diverse viral and bacterial pathogens cause meningitis, leading to varied outcomes and treatment needs.

Purpose of the Study:

To create digital cerebrospinal fluid (CSF) proteome maps for identifying pathogen-specific host responses in meningitis.
To develop a diagnostic tool for classifying meningitis etiology based on host response patterns.

Main Methods:

Construction of a compendium of digital CSF proteome maps.
Analysis of protein influx and reduction patterns in CSF.
Development of a multiprotein LASSO regression model for classification.

Main Results:

Pathogen-type specific protein influxes observed in CSF.
Increased neutrophil-derived proteins in CSF correlated with acute bacterial meningitis.
An 18-protein panel accurately classified bacterial meningitis, viral meningitis, and tick-borne encephalitis.

Conclusions:

CSF proteome profiling reveals distinct host response patterns for different meningitis pathogens.
The identified 18-protein panel offers a promising approach for classifying meningitis etiology.
This research supports future pathogen classification based on host response in meningitis.