Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multimodal Novel Recurrent Laryngeal Nerve Monitoring Techniques in Anterior Cervical Spine Surgery: Initial Experience and Proof of Concept.

The Neurodiagnostic journal·2026
Same author

Efficacy and Safety of an mRNA Seasonal Influenza Vaccine in Adults.

The New England journal of medicine·2026
Same author

ManyNumbers 3: A Multi-Lab Study of Demographic Correlates of Early Number Knowledge.

Developmental science·2026
Same author

Oral Methods of Microbiota Manipulation for Depression Symptoms: A Systematic Review: Méthodes orales de manipulation du microbiote pour traiter les symptômes de dépression : Une revue systématique.

Canadian journal of psychiatry. Revue canadienne de psychiatrie·2025
Same author

Advancing frameless stereotactic navigation for precise targeting of the foramen ovale during radio-frequency thermal ablation (RFTA) for trigeminal neuralgia in anesthetized patients using triggered electromyography.

Acta neurochirurgica·2025
Same author

LOXHD1 is an oncofusion-regulated antigen of ewing sarcoma.

Scientific reports·2025
Same journal

Comparison of Corneal Endothelial and Anterior Segment Changes After Nd:YAG Laser Capsulotomy in Eyes with and without Pseudoexfoliation Syndrome.

Seminars in ophthalmology·2026
Same journal

Longitudinal Structural and Functional Trajectories Following Netarsudil Intensification or Surgical Escalation in Primary Open-Angle Glaucoma.

Seminars in ophthalmology·2026
Same journal

Maternal Diabetes Mellitus During Pregnancy as a Risk Factor for Congenital Nasolacrimal Duct Obstruction in the Offspring - a Large-Scale National Study.

Seminars in ophthalmology·2026
Same journal

Clinical Spectrum and Genetics of Ocular Manifestations in Muscle Eye Brain Disease: A Literature Review.

Seminars in ophthalmology·2026
Same journal

Port Delivery System Vs Monthly Ranibizumab in VEGF-Driven Macular Disease: A Systematic Review and Meta-Analysis.

Seminars in ophthalmology·2026
Same journal

Genome Wide Pleiotropic Analysis Reveals Shared Genetic Architecture and Pathological Basis Between Retinitis Pigmentosa and Relevant Ocular Comorbidities.

Seminars in ophthalmology·2026
See all related articles

Related Experiment Video

Updated: Nov 10, 2025

Ye's Swing Technique for Small-incision Lenticule Extraction Surgery
04:15

Ye's Swing Technique for Small-incision Lenticule Extraction Surgery

Published on: June 27, 2025

200

Small Incision Lenticule Extraction (SMILE): Myths and Realities.

Grace Huang1,2, Samir Melki1,2

  • 1Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.

Seminars in Ophthalmology
|April 6, 2021
PubMed
Summary
This summary is machine-generated.

Small Incision Lenticule Extraction (SMILE) offers an alternative to LASIK eye surgery. This review examines claims of reduced dry eye, faster recovery, and a stronger cornea, distinguishing myths from realities in refractive surgery.

Keywords:
Corneal biomechanicsCorneal sensitivityDry eyeLASIKSMILE

More Related Videos

Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter
05:14

Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter

Published on: September 16, 2025

295
A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva
07:51

A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva

Published on: January 12, 2019

6.9K

Related Experiment Videos

Last Updated: Nov 10, 2025

Ye's Swing Technique for Small-incision Lenticule Extraction Surgery
04:15

Ye's Swing Technique for Small-incision Lenticule Extraction Surgery

Published on: June 27, 2025

200
Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter
05:14

Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter

Published on: September 16, 2025

295
A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva
07:51

A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva

Published on: January 12, 2019

6.9K

Area of Science:

  • Ophthalmology
  • Refractive Surgery
  • Corneal Science

Background:

  • Small Incision Lenticule Extraction (SMILE) has emerged as a significant alternative to LASIK for laser vision correction.
  • This femtosecond laser technique creates and removes an intrastromal lenticule via a small incision, differing from LASIK's flap-based approach.
  • SMILE received USFDA approval for myopia and astigmatism correction in October 2018, marking its recent introduction in the United States.

Purpose of the Study:

  • To critically evaluate prevalent claims associated with SMILE refractive surgery.
  • Key claims under review include reduced iatrogenic dry eye, enhanced corneal sensation recovery, and improved corneal biomechanical strength.
  • The study aims to differentiate scientifically supported outcomes from unsubstantiated assertions regarding SMILE.

Main Methods:

  • Systematic literature review of recent scientific publications on SMILE.
  • Analysis of published outcomes related to dry eye incidence, corneal sensitivity, and biomechanical properties post-SMILE.
  • Comparative assessment of evidence supporting or refuting common SMILE claims.

Main Results:

  • Evidence regarding reduced iatrogenic dry eye post-SMILE requires further investigation.
  • The impact of SMILE on corneal sensation recovery compared to LASIK is still under scrutiny.
  • Preliminary data suggests SMILE may result in a biomechanically stronger cornea, but robust comparative studies are needed.

Conclusions:

  • SMILE is a developing refractive technique with potential advantages, but some claims require more rigorous scientific validation.
  • Further randomized controlled trials are essential to directly compare SMILE outcomes with the established efficacy and safety of LASIK.
  • Long-term data is necessary to fully understand the benefits and limitations of SMILE in refractive surgery.