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Updated: Nov 10, 2025

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
Published on: July 16, 2017
ProDy 2.0: increased scale and scope after 10 years of protein dynamics modelling with Python
She Zhang1, James M Krieger1, Yan Zhang1
1Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Summary:
ProDy, an integrated application programming interface developed for modelling and analysing protein dynamics, has significantly evolved in recent years in response to the growing data and needs of the computational biology community. We present major developments that led to ProDy 2.0: (i) improved interfacing with databases and parsing new file formats, (ii) SignDy for signature dynamics of protein families, (iii) CryoDy for collective dynamics of supramolecular systems using cryo-EM density maps and (iv) essential site scanning analysis for identifying sites essential to modulating global dynamics.
Availability And Implementation:
ProDy is open-source and freely available under MIT License from https://github.com/prody/ProDy.
Supplementary Information:
Supplementary data are available at Bioinformatics online.
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