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How SARS-CoV-2 Transformed the Clinical Laboratory: Challenges and Lessons Learned.

Jonathan M Tsai1,2,3, Nicole V Tolan1,2, Athena K Petrides1,2

  • 1Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.

The Journal of Applied Laboratory Medicine
|April 6, 2021
PubMed
Summary

Clinical laboratories faced significant challenges during the COVID-19 pandemic, including high testing volumes and supply chain issues. Adaptations in information technology and laboratory management were crucial for maintaining operations and diagnostic testing.

Keywords:
COVID-19SARS-CoV-2 PCR testingclinical laboratoryinformaticslaboratory managementlessons learned

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Area of Science:

  • Clinical Laboratory Science
  • Healthcare Management
  • Pandemic Preparedness

Background:

  • The COVID-19 pandemic severely impacted global healthcare systems, including clinical laboratories.
  • Clinical laboratories are vital for diagnostic testing, influencing patient care, infection control, and public health strategies.
  • Information technology and management tools are essential for laboratory operational resilience during crises.

Purpose of the Study:

  • To detail the challenges encountered by clinical laboratory sections during the COVID-19 pandemic.
  • To describe the adaptations implemented within each laboratory section in response to pandemic-related strains.
  • To offer insights and potential solutions for other institutions managing COVID-19 surges or future pandemics.

Main Methods:

  • Case report detailing experiences across clinical laboratory specialties (chemistry, hematology, microbiology, molecular pathology).
  • Analysis of operational strains including high testing volumes, rapid turnaround time demands, and supply chain disruptions.
  • Documentation of evolving testing algorithms and result interpretations based on increasing knowledge of SARS-CoV-2.

Main Results:

  • Clinical laboratory systems and processes were significantly strained by unprecedented testing demands and evolving diagnostic needs.
  • Adaptations were made across all laboratory sections to manage workflow, resource allocation, and quality control.
  • Information technology played a key role in integrating laboratory specialties and facilitating operational adjustments.

Conclusions:

  • Effective information technology and laboratory management are critical for navigating pandemic-induced challenges.
  • The experiences highlight the need for robust, adaptable laboratory infrastructure to ensure continued diagnostic services during public health emergencies.
  • Sharing these adaptations can inform strategies for enhancing preparedness and response in clinical laboratories globally.