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'Rhupus' syndrome.

R S Panush1, N L Edwards, S Longley

  • 1Department of Medicine, College of Medicine, University of Florida.

Archives of Internal Medicine
|July 1, 1988
PubMed
Summary
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Rhupus, a condition with overlapping rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) features, is not a unique syndrome. Its prevalence is low, and understanding rhupus is crucial for distinct patient management and treatment.

Area of Science:

  • Rheumatology
  • Immunology
  • Internal Medicine

Background:

  • Patients with overlapping features of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are occasionally encountered.
  • The term "rhupus" describes these patients, but its distinctness as a syndrome remains unclear.

Purpose of the Study:

  • To determine the frequency of rhupus patients.
  • To ascertain if rhupus represents a unique overlap syndrome distinct from RA or SLE.

Main Methods:

  • Evaluation of approximately 7000 new patients over 11 years.
  • Identification of patients meeting American Rheumatism Association criteria for both RA and SLE.
  • Long-term observation of identified patients.

Main Results:

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  • Six patients met criteria for both RA (average 6.7 criteria) and SLE (average 4.2 criteria).
  • Rhupus prevalence was 0.09%, lower than expected from chance concurrence.
  • Patients' conditions did not typically evolve into classic RA or SLE patterns.

Conclusions:

  • Rhupus exists as a syndrome with shared features of RA and SLE, likely due to coincidental concurrence.
  • Rhupus is not a unique clinical, pathological, or immunological syndrome.
  • Recognizing rhupus is important as its therapy and outcomes differ from isolated RA or SLE.