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Published on: September 30, 2021
Hepatocellular adenomas: recent updates
Haeryoung Kim1, Young Nyun Park2
1Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Insights
Hepatocellular adenoma (HCA) is a complex liver tumor with diverse features. This review updates pathologists on HCA subclassification, aiding accurate diagnosis and patient care.
Area of Science:
- Hepatology
- Pathology
- Molecular Diagnostics
Background:
- Hepatocellular adenoma (HCA) is a benign liver tumor with significant heterogeneity.
- Histomorphological and molecular subclassification of HCA has improved clinical relevance.
- Understanding HCA subtypes is crucial for accurate diagnosis and management.
Purpose of the Study:
- To provide an updated overview of Hepatocellular Adenoma (HCA) from a pathologist's viewpoint.
- To discuss practical challenges and potential pitfalls in HCA diagnosis.
- To highlight the translational impact of HCA subclassification.
Main Methods:
- Review of recent literature on Hepatocellular Adenoma (HCA).
- Analysis of histomorphological and molecular features of HCA subtypes.
- Discussion of diagnostic criteria and clinical implications.
Main Results:
- HCA exhibits significant histomorphological and molecular diversity.
- Established subclassification of HCA aids in differentiating subtypes.
- Specific subtypes of HCA have distinct clinical behaviors and management strategies.
Conclusions:
- Recent updates in HCA subclassification offer significant translational value.
- Pathologists play a key role in accurate HCA diagnosis and management.
- Addressing practical issues in HCA diagnosis is essential for optimal patient outcomes.
Abstract:
Hepatocellular adenoma (HCA) is a heterogeneous entity, from both the histomorphological and molecular aspects, and the resultant subclassification has brought a strong translational impact for both pathologists and clinicians. In this review, we provide an overview of the recent updates on HCA from the pathologists' perspective and discuss several practical issues and pitfalls that may be useful for diagnostic practice.
