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S100A1 as a potential biomarker for the diagnosis of patients with acute aortic dissection

Chenjun Han1, Qiang Liu1, Yuanmin Li1

  • 1Department of Cardio-Thoracic Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

The Journal of International Medical Research
|April 7, 2021
PubMed

Insights

Plasma S100A1 levels are significantly elevated in patients with acute aortic dissection (AAD). This finding suggests S100A1 has potential clinical value for diagnosing this life-threatening cardiovascular disease.

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Discovery
  • Diagnostic Research

Background:

  • Acute aortic dissection (AAD) is a critical cardiovascular emergency.
  • Early and accurate diagnosis of AAD is crucial for patient outcomes.
  • Current diagnostic methods may require further refinement.

Purpose of the Study:

  • To investigate the plasma concentration of S100A1 in patients with AAD.
  • To evaluate the diagnostic value of S100A1 for AAD.
  • To identify S100A1 as a potential risk factor for AAD development.

Main Methods:

  • Retrospective analysis of 78 AAD patients and 77 healthy controls.
  • Measurement of plasma S100A1, D-dimer, hs-CRP, and cTnT using ELISA.
  • Classification of AAD patients based on the Stanford criteria (Type A and Type B).

Main Results:

  • S100A1 concentrations were significantly higher in AAD patients (Stanford A: 4.9±2.6 ng/mL; Stanford B: 3.5±2.2 ng/mL) compared to controls (0.7±0.6 ng/mL).
  • Elevated S100A1 levels correlated with aortic regurgitation, pericardial effusion, and in-hospital mortality.
  • Receiver operating characteristic (ROC) curve analysis yielded an area under the curve of 0.89 for S100A1 in diagnosing AAD.

Conclusions:

  • Plasma S100A1 is markedly elevated in individuals with acute aortic dissection.
  • S100A1 demonstrates significant potential as a diagnostic biomarker for AAD.
  • S100A1 level is identified as an important risk factor in the pathogenesis of AAD.
Abstract

Keywords:
Aortic diseaseS100 proteinbiological markercalcium-binding proteincardiovascular diseasediagnosis

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