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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
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Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
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Neuralgic amyotrophy: an underrecognized entity.

Tae Uk Kim1, Min Cheol Chang2

  • 1Department of Physical Medicine and Rehabilitation, College of Medicine, Dankook University, Cheonan, Republic of Korea.

The Journal of International Medical Research
|April 7, 2021
PubMed
Summary

Neuralgic amyotrophy (NA), a condition causing sudden shoulder pain and arm weakness, is underdiagnosed. Early recognition of its key features is crucial for accurate diagnosis and appropriate treatment to improve patient outcomes.

Keywords:
Neuralgic amyotrophydiagnosismotor weaknessnarrative reviewpaintreatment

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Area of Science:

  • Neurology
  • Immunology

Background:

  • Neuralgic amyotrophy (NA) is often underdiagnosed, with an estimated incidence of 1 per 1000 person-years.
  • Its multifactorial etiology involves immunological, mechanical, or genetic factors.

Purpose of the Study:

  • To provide a comprehensive overview of neuralgic amyotrophy.
  • To cover etiology, clinical presentation, diagnosis, differential diagnosis, treatment, and prognosis.

Main Methods:

  • Review of essential information on NA.
  • Emphasis on clinical history, physical examination, and advanced imaging techniques.

Main Results:

  • NA presents with sudden shoulder pain and patchy flaccid paralysis of the shoulder/arm.
  • Diagnosis relies on clinical findings, confirmed by MRI and MR neurography.
  • Differential diagnosis must exclude conditions like cervical radiculopathy and rotator cuff tears.

Conclusions:

  • Accurate diagnosis of NA is vital to prevent misdiagnosis in patients with shoulder pain and motor weakness.
  • Prognosis is linked to the extent of axonal damage.