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Infection, Infectious Agents and Vascular Disease
Nicola Ielapi1, Francesco Caprino1, Biagio Malizia1
1Interuniversity Center of Phlebolymphology (CIFL). International Research and Educational Program in Clinical and Experimental Biotechnology" at the Department of Surgical and Medical Sciences University Magna Graecia of Catanzaro, Viale Europa 88100 Catanzaro, Italy.
Reviews on Recent Clinical Trials
|April 7, 2021
Summary
Infections by various agents like herpesviruses and bacteria can contribute to vascular disease. This review analyzes key evidence on infections and their role in vascular pathogenesis.
Area of Science:
- Vascular Biology
- Infectious Diseases
- Pathophysiology
Background:
- Infectious agents are implicated in the development of vascular disease and its complications.
- Understanding the link between infections and vascular conditions is crucial for effective management.
Purpose of the Study:
- To review and analyze current information on common infections associated with vascular disease.
- To discuss the primary pathophysiological mechanisms linking infections to vascular conditions.
Main Methods:
- A comprehensive literature search was conducted on Medline, Scopus, and ScienceDirect.
- The review focused on identifying evidence linking specific infectious agents to vascular disease.
Main Results:
- Herpesviruses, parvovirus B19, hepatitis viruses, human immunodeficiency virus (HIV), SARS-CoV-2, Treponema pallidum, Mycobacterium tuberculosis, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans were identified as relevant.
- These agents show a particular association with vascular disease.
Conclusions:
- Infectious agents can disrupt vascular homeostasis and function through mechanisms like vasomotor dysfunction, thrombosis, and atherosclerosis.
- These pathogens can also alter perivascular adipose tissue and promote inflammation, contributing to vascular disease progression.
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