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Collagenous gastritis: Epidemiology and clinical associations
Robert M Genta1, Kevin O Turner2, Christopher J Morgan2
1Inform Diagnostics, Irving, TX, United States; Baylor College of Medicine, Houston, TX, United States.
Insights
Collagenous gastritis (CG) is more common in females and presents with varied symptoms. Its epidemiology suggests distinct causes in children versus adults, often co-occurring with other lymphocytic gastrointestinal disorders.
Area of Science:
- Gastroenterology
- Pathology
- Epidemiology
Background:
- Collagenous gastritis (CG) is a rare condition, making epidemiological studies challenging.
- Understanding CG's characteristics and associations is crucial for diagnosis and management.
Purpose of the Study:
- To investigate the demographic and clinical features of collagenous gastritis.
- To determine associations between CG and other upper gastrointestinal diseases.
Main Methods:
- A case-control study using the IDEA database.
- 168 patients with histopathologically confirmed CG were compared to 1,286,165 controls.
- Odds ratios (OR) and 95% confidence intervals (CI) were calculated.
Main Results:
- CG prevalence was 13 per 100,000 upper endoscopies.
- CG was more frequent in females (OR: 1.69) with a bimodal age distribution (10-19 years and >60 years).
- Associated conditions included celiac sprue, duodenal lymphocytosis, and lymphocytic gastritis; CG persisted in 69% of cases.
Conclusions:
- Epidemiological findings suggest different etiologies for CG in children and adults.
- CG's association with lymphocytic disorders highlights a potential shared pathophysiology.
Background:
the rare occurrence of collagenous gastritis (CG) makes its epidemiology difficult to investigate. We designed a study to determine the demographic and clinical characteristics as well as the associations of CG with other upper gastrointestinal diseases in a large national clinicopathological database.
Methods:
from the IDEA database we extracted all patients with histopathologically documented CG and, in a case-control study, we compared 168 subjects with and 1,286,165 subjects without CG using odds ratios (OR) with their 95% confidence intervals (CI).
Results:
the prevalence of CG was 13 per 100,000 EGDs. CG was significantly more common among female than male patients (OR: 1.69, 95% CI: 1.20-2.39) and was characterized by a bi-modal age distribution (first peak in patients aged 10-19, second peak primarily in females aged >60 years). CG patients presented with diarrhea (18%), anemia (12%), weight loss (11%), and vomiting (10%). CG was significantly associated with other lymphocytic disorders of the upper gastrointestinal tract, including celiac sprue (2.12, 1.55-2.88), duodenal intraepithelial lymphocytosis (3.71, 2.30-5.98), and lymphocytic gastritis (23.2, 10.9-49.5). CG persisted in 69% of patients who underwent multiple consecutive endoscopies.
Conclusions:
the epidemiologic features of collagenous gastritis reflect on different etiologies contributing to its occurrence in children and adults.
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