Novel compounds from Premna herbacea Roxb. with antidiabetic potential

Diabetes mellitus is an epidemic that is growing worldwide at an alarming rate. The need for plant-based drugs to combat this epidemic led to the isolation of three new compounds, namely 1-Benzoyloxy-8-tetradecanoyloxy-geranilane (1), 1-Benzoyloxy-8-(octadec-9ꞌꞌ-enoyl) geranilane (2), and 1-Benzoyloxy-8-octadecanoyloxygeranilane (3), from the roots of Premnaherbacea. Their structures were deciphered by ¹H NMR, ¹³C NMR, and 2D-NMR. In vitro (α-amylase and α-glucosidase inhibitory activity) and in vivo antidiabetic activity (streptozotocin- nicotinamide model) were conducted using various groups for which various biochemical parameters and histopathology studies were done. This study confirmed that 1-Benzoyloxy-8-(octadec-9ꞌꞌ-enoyl) geranilane from roots of Premna herbacea have significant antidiabetic and antioxidant activity, thus indicating a corrective effect on diabetes and its complications.