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Updated: Nov 10, 2025

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
Published on: August 20, 2018
Dithiin diisoimides: Synthesis and their antimicrobial studies
Sumbul Ahmed1, Shahnaz Perveen2, Khalid Mohammed Khan3
1PCSIR, Laboratories Complex, Shahrah-e-Dr. Salimuzzaman Siddiqui, Karachi, Pakistan.
Abstract:
Sixteen derivatives of dithiin diisoimide 2a-2p have been synthesized and screened for antibacterial and antifungal activity. Compounds 2a-2g and 2i-2p are almost same or more active than gentamicine against Acinetobacter. Whereby compound 2,6-didodecyl-1H,5H-pyrrolo[3',4',5,6][1,4]dithiino[2,3-c]pyrrole-1,3,5,7(2H,6H)-tetrone (2d) having zone of inhibition 20 mm against Acinetobacter is the most potent among all these compounds and can be used as lead compound for the treatment of Acinetobacter infection.
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