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Updated: Nov 10, 2025
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Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
Published on: August 20, 2018
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Dithiin diisoimides: Synthesis and their antimicrobial studies
Sumbul Ahmed1, Shahnaz Perveen2, Khalid Mohammed Khan3
1PCSIR, Laboratories Complex, Shahrah-e-Dr. Salimuzzaman Siddiqui, Karachi, Pakistan.
Pakistan Journal of Pharmaceutical Sciences
|April 7, 2021
Summary
Sixteen novel dithiin diisoimide derivatives were synthesized and tested for antimicrobial properties. Compound 2d demonstrated significant antibacterial activity against Acinetobacter, showing potential for treating infections.
Area of Science:
- Medicinal Chemistry
- Organic Synthesis
- Microbiology
Background:
- Acinetobacter infections pose a significant threat due to increasing antibiotic resistance.
- Novel antimicrobial agents are urgently needed to combat resistant bacterial strains.
Purpose of the Study:
- To synthesize and evaluate the antibacterial and antifungal activities of sixteen novel dithiin diisoimide derivatives.
- To identify potent compounds with activity against Acinetobacter.
Main Methods:
- Synthesis of sixteen dithiin diisoimide derivatives (compounds 2a-2p).
- Screening of synthesized compounds for antibacterial and antifungal activity using zone of inhibition assays.
- Comparison of activity against standard antibiotic (gentamicin).
Main Results:
- Compounds 2a-2g and 2i-2p exhibited antibacterial activity comparable to or exceeding that of gentamicin against Acinetobacter.
- Compound 2d, 2,6-didodecyl-1H,5H-pyrrolo[3',4',5,6][1,4]dithiino[2,3-c]pyrrole-1,3,5,7(2H,6H)-tetrone, showed the highest potency with a 20 mm zone of inhibition against Acinetobacter.
- No significant antifungal activity was reported for the tested compounds.
Conclusions:
- Dithiin diisoimide derivatives represent a promising class of compounds for developing new antibacterial agents.
- Compound 2d is identified as a lead compound for further development in treating Acinetobacter infections.
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