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Updated: Nov 10, 2025

Reverse Dissection and DiceCT Reveal Otherwise Hidden Data in the Evolution of the Primate Face
Published on: January 7, 2019
[Gepants and Ditans]
1Department of Neurology, National Hospital Organization Matsue Medical Center.
Abstract:
The calcitonin gene-related peptide (CGRP) has been shown to play a major role in the pathophysiology of migraine in recent years. Studies have suggested that blocking CGRP signaling is an effective preventive and therapeutic strategy in patients with migraine. Triptans, considered the mainstay of antimigraine treatment cause vasoconstriction; however, gepants and ditans (two novel classes of therapeutic agents) inhibit CGRP release but do not show a vasoconstrictor effect. Both these drugs are awaiting clinical approval in Japan as antimigraine medications that can be administered to patients with cardiovascular risk factors and to those with triptan-refractory migraine.
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