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Updated: Nov 10, 2025
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Published on: January 7, 2019
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[Gepants and Ditans]
1Department of Neurology, National Hospital Organization Matsue Medical Center.
Brain and Nerve = Shinkei Kenkyu No Shinpo
|April 7, 2021
Summary
Calcitonin gene-related peptide (CGRP) plays a key role in migraine. Blocking CGRP with new drugs like gepants and ditans offers a safe alternative for patients with cardiovascular risks or those unresponsive to triptans.
Area of Science:
- Neurology
- Pharmacology
Background:
- Calcitonin gene-related peptide (CGRP) is increasingly recognized for its significant role in migraine pathophysiology.
- Current migraine treatments, such as triptans, can cause vasoconstriction, limiting their use in certain patient populations.
Purpose of the Study:
- To review the role of CGRP in migraine.
- To discuss novel therapeutic agents targeting CGRP.
- To highlight the potential of gepants and ditans for patients with cardiovascular risk factors or triptan-refractory migraine.
Main Methods:
- Literature review of studies on CGRP in migraine.
- Analysis of the mechanisms of action for triptans, gepants, and ditans.
- Evaluation of clinical data regarding the safety and efficacy of novel CGRP inhibitors.
Main Results:
- CGRP signaling blockade is a promising strategy for migraine prevention and treatment.
- Gepants and ditans inhibit CGRP release without causing vasoconstriction.
- These novel agents offer a safer alternative for patients with cardiovascular concerns.
Conclusions:
- CGRP antagonists represent a significant advancement in migraine therapy.
- Gepants and ditans provide a valuable therapeutic option for specific patient groups, including those with cardiovascular risk factors and triptan non-responders.
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