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Chondrocalcinosis in surgically resected joints.

L Sokoloff¹, A A Varma

¹Department of Pathology, State University of New York, Stony Brook 11794-8691.

Arthritis and Rheumatism

|June 1, 1988

Summary

Chondrocalcinosis (CC) is six times more common in knee osteoarthritis (OA) joints than in healthy controls. The link between CC and hip osteoarthritis is less clear, and the study couldn't determine which condition causes the other.

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Area of Science:

Rheumatology
Orthopedics
Pathology

Background:

Osteoarthritis (OA) is a degenerative joint disease.
Chondrocalcinosis (CC) is characterized by calcium pyrophosphate dihydrate crystal deposition in cartilage.
The relationship between OA and CC requires further investigation.

Purpose of the Study:

To investigate the association between chondrocalcinosis (CC) and osteoarthritis (OA).

Main Methods:

Histological examination of 338 joint specimens.
Included surgically resected OA knees and hips, and control knees and fractured hips.
Statistical analysis to assess CC prevalence in relation to OA.

Main Results:

A sixfold increased risk of CC in osteoarthritic knees compared to age- and sex-matched controls.
CC was significantly less frequent in hips than in knees.
The association between CC and hip OA was less definitive.

Conclusions:

Knee osteoarthritis is strongly associated with chondrocalcinosis.
The causal relationship between chondrocalcinosis and osteoarthritis, particularly in the hip, remains undetermined.
Further research is needed to elucidate the etiological link between these conditions.

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