Related Experiment Video

Updated: Nov 10, 2025

Author Spotlight: Evaluating Traditional Chinese Therapy for Ankylosing Spondylitis in Mice
04:47

Author Spotlight: Evaluating Traditional Chinese Therapy for Ankylosing Spondylitis in Mice

Published on: October 27, 2023

1.4K

Anti-Inflammation, Immunomodulation and Therapeutic Repair in Current Clinical Trials for the Management of COVID-19

Chenghai Li1,2, Hua Zhao3, Linna Cheng4

  • 1Stem Cell Program of Clinical Research Center, Henan Provincial People's Hospital and People's Hospital of Zhengzhou University, Zhengzhou, 450003, People's Republic of China.

Drug Design, Development and Therapy
|April 7, 2021
PubMed

Insights

This study reviews biological therapies for COVID-19, focusing on anti-inflammatory and immunomodulatory agents. It analyzes current clinical trials and discusses challenges in developing effective biological treatments for SARS-CoV-2 infections.

Area of Science:

  • Virology
  • Immunology
  • Pharmacology

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, necessitates the development of effective therapeutic strategies beyond vaccines.
  • While vaccines are advancing, there remains a critical need for safe and potent biological therapies to combat COVID-19.
  • Current research focuses on biological agents for anti-inflammatory effects, immunomodulation, and tissue repair in COVID-19 patients.

Purpose of the Study:

  • To analyze the implications of ongoing clinical trials for therapeutic biologics in COVID-19.
  • To address key issues and challenges in the development of biological therapies for COVID-19.
  • To provide an in-depth understanding of biological agents targeting host responses in COVID-19.

Main Methods:

  • Review and analysis of current clinical trial data for biological therapies in COVID-19.
  • Examination of therapeutic strategies targeting inflammatory cytokines, including antibodies and inhibitors.
  • Assessment of biological agents for their roles in physiological and pathological host responses.

Main Results:

  • Ongoing clinical trials are exploring diverse biological agents for COVID-19 treatment.
  • Targeting inflammatory cytokines with biological agents presents a promising therapeutic avenue.
  • Understanding host responses is crucial for the effective development of biological therapies.

Conclusions:

  • Biological therapies, particularly those targeting inflammation and immune responses, hold significant potential for COVID-19 treatment.
  • Further research and careful analysis of clinical trials are essential to overcome challenges in developing effective COVID-19 biological therapies.
  • A comprehensive understanding of host-pathogen interactions is vital for advancing biological therapeutic strategies against SARS-CoV-2.
Keywords:
COVID-19cytokine blockadeimmunomodulationtherapeutic repair

More Related Videos

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction08:02

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

Published on: January 22, 2020

5.6K
Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.5K

Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
14.6K
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
274
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
304
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
279
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
786
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
48