Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

610
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
610
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

412
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
412
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

161
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
161
Endoscopic Procedures V: ERCP01:26

Endoscopic Procedures V: ERCP

1.4K
Endoscopic Retrograde Cholangiopancreatography (ERCP) is a diagnostic procedure that combines endoscopy and fluoroscopy to diagnose and treat conditions related to the bile ducts, pancreatic ducts, and gallbladder. This procedure is beneficial for identifying and addressing blockages, gallstones, strictures, and tumors within the biliary or pancreatic systems. ERCP is both diagnostic and therapeutic, offering the ability to visualize and treat identified problems in one session.
Patient...
1.4K
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

1.5K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seladelpar in patients with primary biliary cholangitis and compensated cirrhosis: Efficacy and safety from RESPONSE and ASSURE studies.

Hepatology communications·2026
Same author

Long-Term Use of Fenofibrate as Second-Line Therapy in Primary Biliary Cholangitis: A Retrospective Study.

Alimentary pharmacology & therapeutics·2026
Same author

Unusual Complication of Percutaneous Gastrostomy Tube Replacement.

ACG case reports journal·2025
Same author

Prognostic significance of mild ascites in patients with cirrhosis.

Hepatology (Baltimore, Md.)·2025
Same author

Risk of bleeding after percutaneous liver procedures in patients with cirrhosis: Myth or fact?

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2024
Same author

Simplifying the Diagnosis and Treatment of Hepatitis B Infection: One Step for Addressing Deficits in the Care Cascade, One Leap for Elimination.

Gastro hep advances·2024
Same journal

Landscape of clinical trials and impact of precision medicine in biliary tract cancers in the last 45 years: a systematic review and meta-analysis of biomarker-driven trials.

Translational gastroenterology and hepatology·2026
Same journal

Safely targeting combination TNF and IL-23 using a gut-restricted and orally delivered therapeutic approach: proof-of-concept for the development of SOR102 in ulcerative colitis.

Translational gastroenterology and hepatology·2026
Same journal

Development and validation of a nomogram for predicting postoperative survival in gallbladder cancer.

Translational gastroenterology and hepatology·2026
Same journal

Emphysematous gastritis: a systematic review of reported cases exploring predictors of mortality.

Translational gastroenterology and hepatology·2026
Same journal

Effect of preoperative biliary drainage on peripheral circulating tumor cells after pancreaticoduodenectomy in patients with resectable periampullary carcinoma and obstructive jaundice.

Translational gastroenterology and hepatology·2026
Same journal

The impact of sedation on adenoma and polyp detection rates in colonoscopy: an evidence-informed narrative review.

Translational gastroenterology and hepatology·2026
See all related articles

Related Experiment Video

Updated: Nov 9, 2025

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology
12:36

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

Published on: March 14, 2020

16.8K

Primary sclerosing cholangitis.

Anahita Rabiee1, Marina G Silveira1

  • 1Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA.

Translational Gastroenterology and Hepatology
|April 7, 2021
PubMed
Summary
This summary is machine-generated.

Primary sclerosing cholangitis (PSC) is a rare liver disease causing bile duct damage. Currently, liver transplantation is the only life-extending treatment for advanced PSC, though the disease can recur post-transplant.

Keywords:
Cholangiopathyautoimmune liver diseasemanagementtreatment

More Related Videos

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.5K
A Two-Step Method for Percutaneous Transhepatic Choledochoscopic Lithotomy
03:56

A Two-Step Method for Percutaneous Transhepatic Choledochoscopic Lithotomy

Published on: September 13, 2022

2.6K

Related Experiment Videos

Last Updated: Nov 9, 2025

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology
12:36

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

Published on: March 14, 2020

16.8K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.5K
A Two-Step Method for Percutaneous Transhepatic Choledochoscopic Lithotomy
03:56

A Two-Step Method for Percutaneous Transhepatic Choledochoscopic Lithotomy

Published on: September 13, 2022

2.6K

Area of Science:

  • Hepatology
  • Gastroenterology
  • Immunology

Background:

  • Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease.
  • It involves inflammatory destruction of bile ducts, leading to fibrosis, cirrhosis, and often liver transplantation.
  • PSC is more common in men, typically diagnosed between 30-40 years, and frequently associated with inflammatory bowel disease (IBD).

Purpose of the Study:

  • To provide a comprehensive overview of Primary Sclerosing Cholangitis (PSC).
  • To discuss the etiology, diagnosis, symptoms, complications, and management of PSC.
  • To highlight the role and outcomes of liver transplantation (LT) in end-stage PSC.

Main Methods:

  • Review of existing literature on PSC.
  • Analysis of epidemiological data regarding PSC prevalence and demographics.
  • Summary of clinical presentation, diagnostic criteria, and current management strategies.

Main Results:

  • PSC is characterized by progressive bile duct destruction and is strongly linked to IBD.
  • The etiology is multifactorial, involving genetic susceptibility, environmental factors, and immune response.
  • Cholangiocarcinoma (CCA) is a significant complication with a 10-20% lifetime risk, contributing to mortality.
  • Liver transplantation is required in about 40% of patients and offers excellent outcomes, despite potential recurrence.

Conclusions:

  • PSC is a serious liver condition with no current medical therapy to halt progression.
  • Management focuses on symptom control and complication treatment.
  • Liver transplantation is the primary life-extending therapy for eligible patients with end-stage PSC.