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Updated: Nov 9, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Obesity and its impact on COVID-19
Angélica J M de Leeuw1, Maureen A M Oude Luttikhuis1, Annemarijn C Wellen1
1University Medical Center Groningen (UMCG), University of Groningen, 9700, AD, Groningen, The Netherlands.
Abstract:
The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic has proven a challenge to healthcare systems since its first appearance in late 2019. The global spread and devastating effects of coronavirus disease 2019 (COVID-19) on patients have resulted in countless studies on risk factors and disease progression. Overweight and obesity emerged as one of the major risk factors for developing severe COVID-19. Here we review the biology of coronavirus infections in relation to obesity. In particular, we review literature about the impact of adiposity-related systemic inflammation on the COVID-19 disease severity, involving cytokine, chemokine, leptin, and growth hormone signaling, and we discuss the involvement of hyperactivation of the renin-angiotensin-aldosterone system (RAAS). Due to the sheer number of publications on COVID-19, we cannot be completed, and therefore, we apologize for all the publications that we do not cite.
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