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Updated: Nov 9, 2025

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

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Published on: April 28, 2019

Limbic encephalitis in a COVID-19 patient?

Luca Chiveri¹, Elena Verrengia², Francesco Muscia²

¹Neurology Departement, ASST Ovest Milanese, Via Papa Giovanni Paolo II 20025, Legnano, Italy. lucachiveri@gmail.com.

Journal of Neurovirology

|April 7, 2021

Summary

A 79-year-old woman experienced a neurological confusional syndrome due to SARS-CoV-2 infection. This case highlights limbic system NMR changes in the absence of significant respiratory symptoms.

Keywords:

Covid-19 Limbic encephalitis

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Published on: November 17, 2020

Area of Science:

Neurology
Infectious Diseases
Neuroimaging

Background:

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily targets the respiratory system.
Neurological manifestations of SARS-CoV-2 infection are increasingly recognized, ranging from mild symptoms to severe encephalopathy.

Observation:

A 79-year-old female patient presented with a purely neurological confusional syndrome.
The patient was diagnosed with SARS-CoV-2 infection.
Clinical examination revealed no significant respiratory disease.

Findings:

Nuclear Magnetic Resonance (NMR) imaging revealed alterations within the limbic system.
The neurological symptoms were disproportionate to the lack of respiratory compromise.

Implications:

This case underscores the potential for SARS-CoV-2 to cause isolated neurological dysfunction.
Limbic system involvement may be a key feature in certain SARS-CoV-2 neurological presentations.
Further research is needed to understand the mechanisms of neuroinvasion and the long-term neurological consequences of SARS-CoV-2.