Related Experiment Video

Updated: Nov 9, 2025

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
03:46

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

Published on: October 11, 2018

10.5K

Risk factors for steroid-induced adverse psychological reactions and sleep problems in pediatric acute lymphoblastic

Annelienke M van Hulst1, Shosha H M Peersmann1, Erica L T van den Akker2

  • 1Princess Maxima Center, CS Utrecht, The Netherlands.

Psycho-Oncology
|April 7, 2021
PubMed

Insights

Steroids are vital for treating pediatric acute lymphoblastic leukemia (ALL), but can cause psychological reactions and sleep issues. Identifying risk factors for these side effects in children with ALL is crucial but challenging due to low-quality evidence.

Area of Science:

  • Pediatric Oncology
  • Pharmacology
  • Psychology

Background:

  • Steroids are essential in treating pediatric acute lymphoblastic leukemia (ALL).
  • Steroid treatment can lead to adverse psychological reactions (APRs) and sleep disturbances.
  • These side effects negatively impact the quality of life for children with ALL.

Purpose of the Study:

  • To systematically review existing literature.
  • To identify risk factors associated with steroid-induced APRs and sleep problems in pediatric ALL patients.

Main Methods:

  • Conducted a systematic search across six databases.
  • Screened titles and abstracts, extracted data, and assessed risk of bias and evidence quality.
  • Utilized Quality in Prognosis Studies and Grading of Recommendations Assessment, Development and Evaluation tools.

Main Results:

  • Included 24 articles with heterogeneous measurement methods for APRs and sleep.
  • Evidence quality was generally very low.
  • Steroid type/dose may influence sleep problems, not APRs; younger patients risk behavior issues, older patients risk sleep problems. Genetic factors require replication.

Conclusions:

  • Conclusions on risk factors for steroid-induced APRs/sleep problems in pediatric ALL must be cautious due to low evidence quality and varied methods.
  • Standardized registration of these adverse events and risk factors is needed for future research.
Abstract

Keywords:
acute lymphoblastic leukemiabehavior and behavior mechanismschilddrug-related side effects and adverse reactionsquality of liferisk factorssleepsteroids

More Related Videos

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

891
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

953

Related Concept Videos

Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
264
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
317
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
70
Management of Insomnia01:19

Management of Insomnia

The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
371
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
522
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
1.5K